Monday 25 September

07.30-09.00             EDUCATION TRACK 1: Histocompatibility: your worst nightmare?

CREATOR: Frans Claas, Leiden, The Netherlands

Lectures:

  • Application of Luminex assays before and after transplantation.
  • From actual towards virtual crossmatches.   
  • HLA epitope matching.    
  • Hidden sensitization: the memory B cell repertoire.

 

07.30-09.00             EDUCATION TRACK 2: Live donation

CREATORS: Paolo Muiesan, Birmingham, United Kingdom and Raj Thuraisingham, London, United Kingdom

Lectures:

  • Left lobe replacing right lobe in live liver donation.     
  • Governance and near miss events in live liver donation.
  • Minor clinical abnormalities in kidney donors.
  • Teaching minimally-invasive live donor nephrectomy.

 

08.00-09.00             Full oral sessions

                                Brief oral sessions

 

09:10-10:40             STATE OF THE ART 1 | ORGAN PRESERVATION AND ENHANCEMENTS

CREATORS: Gabriel Oniscu, Edinburgh, United Kingdom and Jacques Pirenne, Leuven, Belgium

2017: A growing need for transplantation and changing demographics that challenge any potential increase in organ transplantation. Clinical efforts and research focus on making more organs function better and creating more organs for the ever-growing demand. The race is on: will it be organ reconditioning or creating more organs off the shelf? This session will discuss some of the recent developments that may make organ shortage a thing of the past

  • Lectures :
  • Organ reconditioning should start in the donor.
  • Ex-situ organ reconditioning: living up to the promise?
  • Origami based tissue engineering
  • Choice cuts: growing organs in alternative environments

 

09:10-10:40             STATE OF THE ART 2 | MIX AND MATCH: THE RIGHT ORGAN FOR THE RIGHT RECIPIENT

CREATORS: Valentin Cuervas-Mons, Madrid, Spain and Eelco de Koning, Leiden, The Netherlands

The right organ for the right patient is a central theme in transplantation. To maintain good clinical transplantation outcome is an increasing challenge in light of both donors and recipients with more unfavourable characteristics that could negatively affect this outcome. In this session we will first focus on global aspects of donation and transplantation and subsequently zoom in on 3 categories of recipients that we commonly encounter in our transplantation clinics. Sergio Leone would name them: The immunized, The old and The diabetic            

  • Lectures :
  • World Overview on Transplantation Activities (A report of the Global Observatory on Donation & Transplantation).
  • The immunized patient.
  • The old patient.
  • The diabetic patient.

 

09:10-10:40             STATE OF THE ART 3 | THE BIOMARKER PERSPECTIVE: PRIME TIME OR PERPETUAL PROMISE?

CREATORS: Oriol Bestard, Barcelona, Spain and Maarten Naesens, Leuven, Belgium

Personalised medicine seems the new Holy Grail in medicine. But is it? And what has been achieved in transplantation?  In this session, we discuss the experiences of large consortia that search for biomarkers in the field of transplantation. Biomarkers for non-invasive diagnosis of rejection, for guidance on immunosuppression and for patient risk stratification. In addition, we learn that the efforts to discover and validate innovative biomarkers are huge and that the pipeline towards clinical implementation is long. Finally, we look into the mirror and the crystal ball,  evaluating the achievements made to date and the promises for the future.

  • Lectures :
  • BIOMARGIN - systems biology for non-invasive diagnosis of rejection.
  • BIO-DRIM - marker-assisted immunosuppression individualisation.
  • CTOT - biomarkers for transplant risk stratification.
  • The biomarker verdict: prime time or perpetual promise?

 

11.10-12.40             BIG BANG 1 | TECHNOLOGY ENHANCED  MEDICINE

CREATORS: Pietro Cippà, Zurich, Switzerland and Olivier Thaunat, Lyon, France

We are living in an fast moving age, where the convergence of rapidly developing technologies are enabling new capabilities with the potential to radically improve and disrupt our day to day life. In this session we invite you to have a glance into the crystal ball to see how the future of transplantation looks like. You will learn a CRISPR way to engineer the human genome and how we will soon operate patients from within thanks to nanorobot surgeons."

  • Lectures :
  • A CRISPR way to engineer the human genome.
  • Operating from within: nanorobotic surgery.
  • How do we exploit best brain in tech, science and med to have a global impact!

 

11.10-12.40             Best abstract challenge

                                Full oral sessions

 

13.00-14.00             Corporate parallel lunch symposia

                                Surrogate Endpoints International Workshop

                                Brief oral sessions

 

14:05-15:35             PLENARY SESSION 2 | TRIALS AND TRIBULATIONS IN TRANSPLANTATION

CREATORS: Marc Dahlke, Regensburg, Germany and Alexandre Loupy, Paris, France

Some of the established frameworks and conventional approaches in transplantation are outdated and hinder further progress in the field: Endpoints such as BPAR may be less relevant in the modern era while surrogate endpoints e.g. for long term Ktx survival are lacking. We herein attempt to shake up your minds a bit and engage in a mind-set that challenges some of the things considered to be "true" or important. Let us rethink the relevance and value of established tools for promotion of progress in clinical science and face the need for change and the challenges that come with it. Welcome to a  session that will be rebellious and provocative but also constructive and productive.

  • Lectures :
  • What to do when randomized controlled trials stop working.
  • I can induce tolerance but nobody wants to believe me.
  • Define Success in the 2017 Transplant World; A Path to happiness.

Key note presentation : Managing Change with Big Data.

 

 

16:00 -17:00            BIG BANG 2 | VALUE AND COSTS OF SCIENCE AND PATIENT CARE IN TRANSPLANTATION: THE UNWANTED TRUTH

CREATORS: Stefan Schneeberger, Innsbruck, Austria and Dorry Segev, Baltimore, United States

Lectures :

  • The price for progress.
  • The changing circumstances in health care and their consequences.
  • The price for patients satisfaction.

 

16.00-17.00             Modern education

                                Brief oral sessions

 

16.00-18.00             Full oral sessions

                                               

17.00-18.00             Transplant campfire

                                The Devil's Advocate - Contradictory discussion of Basic Science

                                Brief oral sessions

 

18.00-19.30             Corporate Plenary Symposium