Monday 25 September
07.30-09.00 EDUCATIONAL TRACK SESSION 1 | HISTOCOMPATIBILITY: YOUR WORST NIGHTMARE?
CHAIRS: Frans Claas, Leiden, The Netherlands
David Taube, London, United Kingdom
07:30 Learning objectives Assessment
07.45 Application of Luminex® assays before and after transplantation
Christophe Legendre, Paris, France
08.00 From actual towards virtual crossmatch
Craig Taylor, Cambridge, United Kingdom
08.15 HLA epitope matching
Sebastiaan Heidt, Leiden, The Netherlands
08.30 Hidden sensitization: the memory B cell repertoire
Oriol Bestard, Barcelona, Spain
07.30-09.00 EDUCATIONAL TRACK SESSION 2 | LIVE DONATION
CHAIRS: Paolo Muiesan, Birmingham, United Kingdom
Raj Thuraisingham, London, United Kingdom
07.45 Laparoscopy replacing open surgery in live liver donation
Ki Hun Kim, Seoul, South Korea
08.00 Governance and near miss events in live liver donation
Juan Carlos García-Valdecasas, Barcelona, Spain
08.15 Minor clinical abnormalities in kidney donors
Rachel Hilton, London, United Kingdom
08.30 Teaching minimally-invasive live donor nephrectomy
Lloyd Ratner, New York, United States
08.00-09.00 Full oral sessions
Brief oral sessions
09:10-10:40 STATE OF THE ART 1 | ORGAN PRESERVATION AND ENHANCEMENTS
2017: The limitation of available organs and changing demographics are challenges hindering a more rapid growth in organ transplantation. Clinical efforts and a research focus towards making more organs functioning better and increasing the number of organs available for transplantation are ever more important goals. The race is on: will it be organ reconditioning or creating more organs off the shelf? This session will discuss some of the recent developments that may make organ shortage a thing of the past.
CREATED BY: Gabriel Oniscu, Edinburgh, United Kingdom
Jacques Pirenne, Leuven, Belgium
CHAIRS: Constantino Fondevila, Barcelona, Spain
Jacques Pirenne, Leuven, Belgium
09.10 Organ reconditioning should start in the donor
Gabriel Oniscu, Edinburgh, United Kingdom
09.30 Ex-situ organ reconditioning: living up to the promise?
Peter Friend, Oxford, United Kingdom
09.50 Origami based tissue engineering
Nathaniel Hwang, Seoul, South Korea
10.10 Choice cuts: growing organs in alternative environments
Pablo Juan Ross, Davis, United States
09.10-10.40 STATE OF THE ART 2 | MIX AND MATCH: THE RIGHT ORGAN FOR THE RIGHT RECIPIENT
Selecting the right organ for the right patient is an increasing challenge in transplantation. To maintain good outcomes is an increasing challenge in light of both donors and recipients presenting with more unfavorable characteristics. In this session we will focus on global aspects of donation and transplantation and subsequently zoom in on 3 categories of recipients that we commonly encounter in our transplantation clinics. Sergio Leone would name them: The Immunized, The Old and The Diabetic.
CREATED BY: Valentin Cuervas-Mons, Madrid, Spain
Eelco de Koning, Leiden, The Netherlands
CHAIRS: Valentín Cuervas-Mons, Madrid, Spain
Eelco de Koning, Leiden, The Netherlands
09.10 World Overview on Transplantation Activities (a report of the Global Observatory on Donation & Transplantation)
Beatriz Mahillo, Madrid, Spain
09.30 The immunized patient
Frans Claas, Leiden, The Netherlands
09.50 The old patient
Uwe Heeman, Munich, Germany
10.10 The diabetic patient
Raja Kandaswamy, Minneapolis, United States
09:10-10:40 STATE OF THE ART 3 | THE BIOMARKER PERSPECTIVE: PRIME TIME OR PERPETUAL PROMISE?
Personalised treatment seems the new Holy Grail in medicine. But is it achievable and how far have we advanced in transplantation at this point? In this session, we discuss the experience of large consortia in their search for biomarkers for non-invasive diagnosis of rejection, for guidance on immunosuppression and for patient risk stratification. In addition, we will show that the efforts to discover and validate innovative biomarkers are huge and that the pipeline towards clinical implementation is long. Finally, we look into the mirror but also the crystal ball, evaluating the achievements made to date and the promises for the future.
CREATED BY: Oriol Bestard, Barcelona, Spain
Maarten Naesens, Leuven, Belgium
CHAIRS: Oriol Bestard, Barcelona, Spain
Alberto Sanchez-Fueyo, London, United Kingdom
09.10 BIOMARGIN - systems biology for non-invasive diagnosis of rejection
Wilfried Gwinner, Hannover, Germany
09.30 BIO-DRIM - marker-assisted immunosuppression individualization
Petra Reinke, Berlin, Germany
09.50 CTOT - biomarkers for transplant risk stratification
Peter Heeger, New York, United States
10.10 The biomarker verdict: prime time or perpetual promise?
Dany Anglicheau, Paris, France
11.10-12.40 BIG BANG 1 | TECHNOLOGY ENHANCED MEDICINE
We are living in a fast forward moving age, where the convergence of rapidly developing technologies are holding the potential to radically improve and disrupt our day to day life. In this session we invite you to have a glance into the future to see how the transplantation will look like years ahead. You will learn a CRISPR way to engineer the human genome, realize that soft robots can support or replace organ function and be impressed by the enormous potential of stem cell biology for generation of human tissues and organs.
CREATED BY: Pietro Cippà, Zurich, Switzerland
Olivier Thaunat, Lyon, France
CHAIRS:Pietro Cippà, Zurich, Switzerland
Olivier Thaunat, Lyon, France
11.10 A CRISPR way to engineer the human genome
Angelo Lombardo, Milan, Italy
11.40 Cardiovascular devices with a difference - light reflecting balloons and soft robots
Ellen Roche, Cambridge, United States
12.00 KEYNOTE: Genetic, Epigenetic and Cellular approaches to combat disease and aging
Juan Carlos Izpisua Belmonte, La Jolla, United States
13.00-14.00 FUTURE LEADERS ON STAGE: LIFE-CHANGING STORIES
The Young Professionals in Transplantation have launched a competition to future leaders in transplantation to give a seminal presentation at the ESOT congress. Young Professionals have been selected through a call for action on Social Media. Have a look at the exciting and inspirational presenters that have been selected under 40 years old.
CREATED BY: Francesca Tinti, Rome, Italy
Mohammed Zeeshan Akhtar, Oxford, United Kingdom
CHAIRS: Francesca Tinti, Rome, Italy
Mohammed Zeeshan Akhtar, Oxford, United Kingdom
13.00 A very personal story of success and failure:
My journey to social media
Omar Taco, Barcelona, Spain
13.20 Life-changing event:
“To improve is to change, to be perfect is to change often.” (Winston Churchill)
Natalie Vallant, Innsbruck, Austria
13.40 Life-changing event:
A Love Worth Giving
Luke Yates, London, United Kingdom
11.10-12.40 Best abstract challenge
Full oral sessions
13.00-14.00 Corporate parallel lunch symposia
Surrogate Endpoints International Workshop
Brief oral sessions
Elevator Pitch sessions
14:05-15:35 PLENARY SESSION 2 | TRIALS AND TRIBULATIONS IN TRANSPLANTATION
Some of the established frameworks and conventional approaches in transplantation are outdated and hinder further progress in the field: endpoints such as BPAR may be less relevant in the modern era while surrogate endpoints e.g. for long term KTx survival are lacking. We herein attempt to shake up your minds and engage in a mind-set that challenges some of the things considered to be ‘true’ or important. Let us rethink the relevance and value of established tools for promotion of progress in clinical science and face the need for change and the challenges that come with it. Welcome to a session that will be rebellious and provocative but also constructive and productive.
CREATED BY: Mark Dahlke, Regensburg, Germany
Alexandre Loupy, Paris, France
CHAIRS: Robert Montgomery, New York, United States
Gabriel Oniscu, Edinburgh, United Kingdom
14.05 What to do when randomized controlled trials stop working
Alexandre Loupy, Paris, France
14.25 I can induce tolerance but nobody wants to believe me
Alberto Sánchez, London, United Kingdom
14.45 Define Success in the 2017 transplant world; a path to happiness
Flavio Vincenti, San Francisco, United States
15.05 Managing change with big data
16:00 -17:00 BIG BANG 2 | VALUE AND COSTS OF SCIENCE AND PATIENT CARE IN TRANSPLANTATION: THE UNWANTED TRUTH
The idea of this session is to critically reflect on the value and cost-relationship in transplantation – in reference to science, progress, quality of life, patient behaviour including compliance but also regulatory obligations such as working week regulations. The value of life and costs of suffering as well as the implications of money and patient but also physician behaviour are much debated issues in modern health care. We will touch on strategic thinking in research funding, the implementation from lab inventions to successful enterprises and what can be learned from the free market. In this session, we aim to draw a modern picture of the actual circumstances in healthcare with respect to both the finances of a treatment, but also patient behaviour and their implications on outcome and quality of care. You will experience a different and fresh view on patient care in a rapidly changing environment.
CREATED BY: Stefan Schneeberger, Innsbruck, Austria
Dorry Segev, Baltimore, United States
CHAIRS: Stefan Schneeberger, Innsbruck, Austria
Dorry Segev, Baltimore, United States
16.00 The price for progress
Wim Bens, Maastricht, The Netherlands
16.20 The changing circumstances in health care and their consequences
Scott Halpern, Philadelphia, United States
16.40 The price for patient satisfaction
Sheila Jowsey, Rochester, United States
16.00-17.00 Brief oral sessions
16.00-18.00 Full oral sessions
16.00-18.00 FROM LEARNERS TO LEADERS AND CAMPFIRE SESSION
CHAIR: Wojciech Polak, Rotterdam, The Netherlands
16:00 ESOT Education - ESOT Transplant Live & Live Events
John Forsythe, Edinburgh, United Kingdom
Frank Dor, London, United Kingdom
16:10 KEYNOTE: Time is now – modern education
William Plant, Cork, Ireland
16:40 From learners to leaders: introducing the Freudian Walk
O Captain, My Captain – how the journey continues
Luca Toti, Rome, Italy
16:50 A growing experience – part 1: keeping the balance
Maruska Nizzi, Milan, Italy
17:00 Freudian Walk (3 crews/3 topics about learning/communicating/sharing)
Crew 1 with captain Wojciech Polak, Rotterdam, The Netherlands
Crew 2 with captain Jacopo Romagnoli, Rome, Italy
Crew 3 with captain Luca Toti, Rome, Italy
The Campfire
17:20 A growing experience - part 2: tips & tricks from senior experts
Maruska Nizzi, Milan, Italy
17:30 Campfire Live (3 crews/3 campfires)
Crew 1 mentored by captain Wojciech Polak, Rotterdam, The Netherlands
Crew 2 mentored by captain Jacopo Romagnoli, Rome, Italy
Crew 3 mentored by captain Luca Toti, Rome, Italy
17:50 Sharing is Caring – a “post” to the Leaders
Maruska Nizzi, Milan, Italy
Luca Toti, Rome, Italy
17.00-18.00 THE DEVIL’S ADVOCATE: A MODERATED CONTROVERSY IN BASIC SCIENCE
The format of this session will be the presentation of the article by the author followed by a critical discussion by the “opponent” and a rebuttal and general discussion with the audience. It will be a highly interactive session.
CREATED BY: Olivier Thaunat, Lyon, France
Thomas Wekerle, Vienna, Austria
New insights in the priming of recipient's immune system
Donor dendritic cell-derived exosomes promote allograft-targeting immune response.
Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Stolz DB, Erdos G, Sullivan ML, Gibson GA, Watkins SC, Larregina AT, Morelli AE. J Clin Invest. 2016 Aug 1;126(8):2805-20. doi: 10.1172/JCI84577. Epub 2016 Jun 27
17:00 Defender: Adrian Morelli, Pittsburgh, United States
17:20 Opponent: Gavin Pettigrew, Cambridge, United Kingdom
17:30 Discussion
Impact of microbiota on transplantation outcomes
The composition of the microbiota modulates allograft rejection
Yuk Man Lei, Luqiu Chen, Ying Wang, Andrew T. Stefka, Luciana L. Molinero, Betty Theriault, Keston Aquino-Michaels, Ayelet S. Sivan, Cathryn R. Nagler, Thomas F. Gajewski, Anita S. Chong, Caroline Bartman and Maria-Luisa Alegre. Journal of Clinical Investigation, June 20, 2016
17:40 Defender: Maria Luisa Alegre, Chicago, United States
17:50 Opponent
18:00 Discussion
17.00-18.00 Brief oral sessions
18.00-19.30 Corporate Plenary Symposium