Monday 25 September

07.30-09.00             EDUCATION TRACK 1: Histocompatibility: your worst nightmare?

CREATOR: Frans Claas, Leiden, The Netherlands

CHAIRS: Frans Claas, Leiden, The Netherlands and David Taube, London, United Kingdom

Lectures:

  • Application of Luminex assays before and after transplantation
    Christophe Legendre, Paris, France
  • From actual towards virtual crossmatches
    Craig Taylor, Cambridge, United Kingdom
  • HLA epitope matching
    Sebastiaan Heidt, Leiden, The Netherlands
  • Hidden sensitization: the memory B cell repertoire
    Oriol Bestard, Barcelona, Spain

 

07.30-09.00             EDUCATION TRACK 2: Live donation

CREATORS: Paolo Muiesan, Birmingham, United Kingdom and Raj Thuraisingham, London, United Kingdom

CHAIRS: Paolo Muiesan, Birmingham, United Kingdom and Raj Thuraisingham, London, United Kingdom

Lectures:

  • Left lobe replacing right lobe in live liver donation
    Ki Hun Kim, Seoul, South Korea
  • Governance and near miss events in live liver donation
    Juan Carlos García-Valdecasas, Barcelona, Spain
  • Minor clinical abnormalities in kidney donors
    Rachel Hilton, London, United Kingdom
  • Teaching minimally-invasive live donor nephrectomy
    Lloyd Ratner, New York, United States

 

08.00-09.00             Full oral sessions

                                Brief oral sessions

 

09:10-10:40             STATE OF THE ART 1 | ORGAN PRESERVATION AND ENHANCEMENTS

CREATORS: Gabriel Oniscu, Edinburgh, United Kingdom and Jacques Pirenne, Leuven, Belgium

2017: A growing need for transplantation and changing demographics that challenge any potential increase in organ transplantation. Clinical efforts and research focus on making more organs function better and creating more organs for the ever-growing demand. The race is on: will it be organ reconditioning or creating more organs off the shelf? This session will discuss some of the recent developments that may make organ shortage a thing of the past

CHAIRS: Constantino Fondevila, Barcelona, Spain and Jacques Pirenne, Leuven, Belgium

Lectures :

  • Organ reconditioning should start in the donor
    Gabriel Oniscu, Edinburgh, United Kingdom
  • Ex-situ organ reconditioning: living up to the promise?
    Peter Friend, Oxford, United Kingdom
  • Origami based tissue engineering
    Nathaniel Hwang, Seoul, South Korea
  • Choice cuts: growing organs in alternative environments
    Pablo Juan Ross, Davis, United States

 

09:10-10:40             STATE OF THE ART 2 | MIX AND MATCH: THE RIGHT ORGAN FOR THE RIGHT RECIPIENT

CREATORS: Valentin Cuervas-Mons, Madrid, Spain and Eelco de Koning, Leiden, The Netherlands

The right organ for the right patient is a central theme in transplantation. To maintain good clinical transplantation outcome is an increasing challenge in light of both donors and recipients with more unfavourable characteristics that could negatively affect this outcome. In this session we will first focus on global aspects of donation and transplantation and subsequently zoom in on 3 categories of recipients that we commonly encounter in our transplantation clinics. Sergio Leone would name them: The immunized, The old and The diabetic            

CHAIRS: Valentin Cuervas-Mons, Madrid, Spain and Eelco de Koning, Leiden, The Netherlands

Lectures :

  • World Overview on Transplantation Activities (A report of the Global Observatory on Donation & Transplantation)
    Beatriz Mahillo, Madrid, Spain
  • The immunized patient
    Frans Claas, Leiden, The Netherlands
  • The old patient
    Uwe Heeman, Munich, Germany
  • The diabetic patient
    Raja Kandaswamy, Minneapolis, United States

 

09:10-10:40             STATE OF THE ART 3 | THE BIOMARKER PERSPECTIVE: PRIME TIME OR PERPETUAL PROMISE?

CREATORS: Oriol Bestard, Barcelona, Spain and Maarten Naesens, Leuven, Belgium

Personalised medicine seems the new Holy Grail in medicine. But is it? And what has been achieved in transplantation?  In this session, we discuss the experiences of large consortia that search for biomarkers in the field of transplantation. Biomarkers for non-invasive diagnosis of rejection, for guidance on immunosuppression and for patient risk stratification. In addition, we learn that the efforts to discover and validate innovative biomarkers are huge and that the pipeline towards clinical implementation is long. Finally, we look into the mirror and the crystal ball,  evaluating the achievements made to date and the promises for the future.

CHAIRS: Oriol Bestard, Barcelona, Spain and Alberto Sánchez-Fueyo, London, United Kingdom

Lectures :

  • BIOMARGIN - systems biology for non-invasive diagnosis of rejection
    Wilfried Gwinner, Hannover, Germany
  • BIO-DRIM - marker-assisted immunosuppression individualisation
    Petra Reinke, Berlin, Germany
  • CTOT - biomarkers for transplant risk stratification
    Peter Heeger, New York, United States
  • The biomarker verdict: prime time or perpetual promise?
    Dany Anglicheau, Paris, France

 

11.10-12.40             BIG BANG 1 | TECHNOLOGY ENHANCED  MEDICINE

CREATORS: Pietro Cippà, Zurich, Switzerland and Olivier Thaunat, Lyon, France

We are living in an fast moving age, where the convergence of rapidly developing technologies are enabling new capabilities with the potential to radically improve and disrupt our day to day life. In this session we invite you to have a glance into the crystal ball to see how the future of transplantation looks like. You will learn a CRISPR way to engineer the human genome and how we will soon operate patients from within thanks to nanorobot surgeons."

CHAIRS: Pietro Cippà, Zurich, Switzerland and Olivier Thaunat, Lyon, France

Lectures :

  • A CRISPR way to engineer the human genome
    Angelo Lombardo, Milan, Italy
  • Operating from within: nanorobotic surgery
    Speaker to be confirmed
  • KEYNOTE Juan Carlos Izpisua Belmonte, La Jolla, USA
  • Ellen Roche, Cambridge, United States

 

11.10-12.40             Best abstract challenge

                                Full oral sessions

 

13.00-14.00             Corporate parallel lunch symposia

                                Surrogate Endpoints International Workshop

                                Brief oral sessions

                                Elevator Pitch sessions

 

14:05-15:35             PLENARY SESSION 2 | TRIALS AND TRIBULATIONS IN TRANSPLANTATION

CREATORS: Marc Dahlke, Regensburg, Germany and Alexandre Loupy, Paris, France

Some of the established frameworks and conventional approaches in transplantation are outdated and hinder further progress in the field: Endpoints such as BPAR may be less relevant in the modern era while surrogate endpoints e.g. for long term Ktx survival are lacking. We herein attempt to shake up your minds a bit and engage in a mind-set that challenges some of the things considered to be "true" or important. Let us rethink the relevance and value of established tools for promotion of progress in clinical science and face the need for change and the challenges that come with it. Welcome to a  session that will be rebellious and provocative but also constructive and productive.

CHAIRS: Bob Montgomery, New York, United States and Gabriel Oniscu, Edinburgh, United Kingdom

Lectures :

  • What to do when randomized controlled trials stop working
    Alexandre Loupy, Paris, France
  • I can induce tolerance but nobody wants to believe me
    Alberto Sánchez-Fueyo, London, United Kingdom
  • Define Success in the 2017 Transplant World; A Path to happiness
    Flavio Vincenti, San Francisco, United States
  • KEYNOTE : Managing Change with Big Data.

 

16:00 -17:00            BIG BANG 2 | VALUE AND COSTS OF SCIENCE AND PATIENT CARE IN TRANSPLANTATION: THE UNWANTED TRUTH

CREATORS: Stefan Schneeberger, Innsbruck, Austria and Dorry Segev, Baltimore, United States

The idea of this session is to critically reflect on the value and cost relationship in transplantation – in reference to science, progress, quality of life, patient behaviour including compliance but also regulatory obligations such as working week regulations. The value of life and costs of suffering as well as the implications of money and patient but also physician behaviour are much debated issues in modern health care. We will touch on strategic thinking in research funding, the implementation from lab invention to successful enterprises and what can be learned from the free market. In this session, we aim to draw a modern picture of the actual circumstances in Health Care with respect to both the finances of a treatment, but also patient behaviour and their implications on quality of care. You will experience a different and fresh view on patient care in a rapidly changing environment.

CHAIRS: Stefan Schneeberger, Innsbruck, Austria and Dorry Segev, Baltimore, United States

Lectures :

  • The price for progress
    Wim Bens, Maastricht, The Netherlands
  • The changing circumstances in health care and their consequences
    Scott Halpern, Philadelphia, United States
  • The price for patients satisfaction
    Sheila Jowsey, Rochester, United States

 

16.00-17.00             Modern education

                                Brief oral sessions

 

16.00-18.00             Full oral sessions

                                               

17.00-18.00             Transplant campfire

                                The Devil's Advocate - Contradictory discussion of Basic Science

                                Brief oral sessions

 

18.00-19.30             Corporate Plenary Symposium