Monday 25 September

07.30-09.00          EDUCATIONAL TRACK SESSION 1 | HISTOCOMPATIBILITY: YOUR WORST NIGHTMARE?

CHAIRS: Frans Claas, Leiden, The Netherlands
              David Taube, London, United Kingdom

07:30                     Learning objectives Assessment

07.45                      Application of Luminex® assays before and after transplantation
                               Christophe Legendre, Paris, France

08.00                      From actual towards virtual crossmatch
                               Craig Taylor, Cambridge, United Kingdom

08.15                      HLA epitope matching
                               Sebastiaan Heidt, Leiden, The Netherlands

08.30                      Hidden sensitization: the memory B cell repertoire
                               Oriol Bestard, Barcelona, Spain

 

07.30-09.00          EDUCATIONAL TRACK SESSION 2 | LIVE DONATION

CHAIRS: Paolo Muiesan, Birmingham, United Kingdom
              Raj Thuraisingham, London, United Kingdom

07.45                      Laparoscopy replacing open surgery in live liver donation
                               Ki Hun Kim, Seoul, South Korea

08.00                      Governance and near miss events in live liver donation
                               Juan Carlos García-Valdecasas, Barcelona, Spain

08.15                      Minor clinical abnormalities in kidney donors
                               Rachel Hilton, London, United Kingdom

08.30                      Teaching minimally-invasive live donor nephrectomy
                               Lloyd Ratner, New York, United States

08.00-09.00             Full oral sessions

                               Brief oral sessions

 

09:10-10:40             STATE OF THE ART 1 | ORGAN PRESERVATION AND ENHANCEMENTS

2017: The limitation of available organs and changing demographics are challenges hindering a more rapid growth in organ transplantation. Clinical efforts and a research focus towards making more organs functioning better and increasing the number of organs available for transplantation are ever more important goals. The race is on: will it be organ reconditioning or creating more organs off the shelf? This session will discuss some of the recent developments that may make organ shortage a thing of the past.

CREATED BY: Gabriel Oniscu, Edinburgh, United Kingdom
                       Jacques Pirenne, Leuven, Belgium

CHAIRS: Constantino Fondevila, Barcelona, Spain
              Jacques Pirenne, Leuven, Belgium

09.10                      Organ reconditioning should start in the donor           
                               Gabriel Oniscu, Edinburgh, United Kingdom

09.30                      Ex-situ organ reconditioning: living up to the promise?
                               Peter Friend, Oxford, United Kingdom

09.50                      Origami based tissue engineering
                               Nathaniel Hwang, Seoul, South Korea

10.10                      Choice cuts: growing organs in alternative environments
                               Pablo Juan Ross, Davis, United States

 

09.10-10.40          STATE OF THE ART 2 | MIX AND MATCH: THE RIGHT ORGAN FOR THE RIGHT RECIPIENT

Selecting the right organ for the right patient is an increasing challenge in transplantation. To maintain good outcomes is an increasing challenge in light of both donors and recipients presenting with more unfavorable characteristics. In this session we will focus on global aspects of donation and transplantation and subsequently zoom in on 3 categories of recipients that we commonly encounter in our transplantation clinics. Sergio Leone would name them: The Immunized, The Old and The Diabetic.

CREATED BY: Valentin Cuervas-Mons, Madrid, Spain
                       Eelco de Koning, Leiden, The Netherlands

CHAIRS: Valentín Cuervas-Mons, Madrid, Spain
              Eelco de Koning, Leiden, The Netherlands

09.10                      World Overview on Transplantation Activities (a report of the Global Observatory on Donation & Transplantation)
                               Beatriz Mahillo, Madrid, Spain

09.30                      The immunized patient      
                               Frans Claas, Leiden, The Netherlands

09.50                      The old patient
                               Uwe Heeman, Munich, Germany

10.10                      The diabetic patient
                               Raja Kandaswamy, Minneapolis, United States

 

09:10-10:40             STATE OF THE ART 3 | THE BIOMARKER PERSPECTIVE: PRIME TIME OR PERPETUAL PROMISE?

Personalised treatment seems the new Holy Grail in medicine. But is it achievable and how far have we advanced in transplantation at this point? In this session, we discuss the experience of large consortia in their search for biomarkers for non-invasive diagnosis of rejection, for guidance on immunosuppression and for patient risk stratification. In addition, we will show that the efforts to discover and validate innovative biomarkers are huge and that the pipeline towards clinical implementation is long. Finally, we look into the mirror but also the crystal ball, evaluating the achievements made to date and the promises for the future.

CREATED BY: Oriol Bestard, Barcelona, Spain
                       Maarten Naesens, Leuven, Belgium

CHAIRS: Oriol Bestard, Barcelona, Spain
              Alberto Sanchez-Fueyo, London, United Kingdom

09.10                      BIOMARGIN - systems biology for non-invasive diagnosis of rejection
                               Wilfried Gwinner, Hannover, Germany

09.30                      BIO-DRIM - marker-assisted immunosuppression individualization
                               Petra Reinke, Berlin, Germany 

09.50                      CTOT - biomarkers for transplant risk stratification
                               Peter Heeger, New York, United States

10.10                      The biomarker verdict: prime time or perpetual promise?
                               Dany Anglicheau,  Paris, France

 

11.10-12.40             BIG BANG 1 | TECHNOLOGY ENHANCED  MEDICINE

We are living in a fast forward moving age, where the convergence of rapidly developing technologies are holding the potential to radically improve and disrupt our day to day life. In this session we invite you to have a glance into the future to see how the transplantation will look like years ahead. You will learn a CRISPR way to engineer the human genome, realize that soft robots can support or replace organ function and be impressed by the enormous potential of stem cell biology for generation of human tissues and organs.

CREATED BY: Pietro Cippà, Zurich, Switzerland
                       Olivier Thaunat, Lyon, France

CHAIRS:Pietro Cippà, Zurich, Switzerland
              Olivier Thaunat, Lyon, France

11.10                      A CRISPR way to engineer the human genome
                               Angelo Lombardo, Milan, Italy

11.40                      Cardiovascular devices with a difference - light reflecting balloons and soft robots
                               Ellen Roche, Cambridge, United States

12.00                      KEYNOTE: Genetic, Epigenetic and Cellular approaches to combat disease and aging
                               Juan Carlos Izpisua Belmonte, La Jolla, United States

 

13.00-14.00          FUTURE LEADERS ON STAGE: LIFE-CHANGING STORIES

The Young Professionals in Transplantation have launched a competition to future leaders in transplantation to give a seminal presentation at the ESOT congress. Young Professionals have been selected through a call for action on Social Media. Have a look at the exciting and inspirational presenters that have been selected under 40 years old.

CREATED BY: Francesca Tinti, Rome, Italy
                       Mohammed Zeeshan Akhtar, Oxford, United Kingdom

CHAIRS: Francesca Tinti, Rome, Italy
              Mohammed Zeeshan Akhtar, Oxford, United Kingdom

13.00                      A very personal story of success and failure:
                               My journey to social media
                               Omar Taco, Barcelona, Spain

13.20                      Life-changing event:
                               “To improve is to change, to be perfect is to change often.” (Winston Churchill)
                               Natalie Vallant, Innsbruck, Austria

13.40                      Life-changing event:
                               A Love Worth Giving
                               Luke Yates, London, United Kingdom

 

11.10-12.40             Best abstract challenge

                                Full oral sessions

 

13.00-14.00             Corporate parallel lunch symposia

                                Surrogate Endpoints International Workshop

                                Brief oral sessions

                                Elevator Pitch sessions

 

14:05-15:35             PLENARY SESSION 2 | TRIALS AND TRIBULATIONS IN TRANSPLANTATION

Some of the established frameworks and conventional approaches in transplantation are outdated and hinder further progress in the field: endpoints such as BPAR may be less relevant in the modern era while surrogate endpoints e.g. for long term KTx survival are lacking. We herein attempt to shake up your minds and engage in a mind-set that challenges some of the things considered to be ‘true’ or important. Let us rethink the relevance and value of established tools for promotion of progress in clinical science and face the need for change and the challenges that come with it. Welcome to a session that will be rebellious and provocative but also constructive and productive.

CREATED BY: Mark Dahlke, Regensburg, Germany
                       Alexandre Loupy, Paris, France

CHAIRS: Robert Montgomery, New York, United States
              Gabriel Oniscu, Edinburgh, United Kingdom

14.05                      What to do when randomized controlled trials stop working
                               Alexandre Loupy, Paris, France

14.25                      I can induce tolerance but nobody wants to believe me
                               Alberto Sánchez, London, United Kingdom

14.45                      Define Success in the 2017 transplant world; a path to happiness
                               Flavio Vincenti, San Francisco, United States

15.05                      Managing change with big data

 

16:00 -17:00            BIG BANG 2 | VALUE AND COSTS OF SCIENCE AND PATIENT CARE IN TRANSPLANTATION: THE UNWANTED TRUTH

The idea of this session is to critically reflect on the value and cost-relationship in transplantation – in reference to science, progress, quality of life, patient behaviour including compliance but also regulatory obligations such as working week regulations. The value of life and costs of suffering as well as the implications of money and patient but also physician behaviour are much debated issues in modern health care. We will touch on strategic thinking in research funding, the implementation from lab inventions to successful enterprises and what can be learned from the free market. In this session, we aim to draw a modern picture of the actual circumstances in healthcare with respect to both the finances of a treatment, but also patient behaviour and their implications on outcome and quality of care. You will experience a different and fresh view on patient care in a rapidly changing environment.

CREATED BY: Stefan Schneeberger, Innsbruck, Austria
                       Dorry Segev, Baltimore, United States

CHAIRS: Stefan Schneeberger, Innsbruck, Austria
              Dorry Segev, Baltimore, United States

16.00                      The price for progress
                               Wim Bens, Maastricht, The Netherlands

16.20                      The changing circumstances in health care and their consequences
                               Scott Halpern, Philadelphia, United States

16.40                      The price for patient satisfaction
                               Sheila Jowsey, Rochester, United States

 

16.00-17.00             Brief oral sessions

                              

16.00-18.00             Full oral sessions

                                               

16.00-18.00           FROM LEARNERS TO LEADERS AND CAMPFIRE SESSION

CHAIR: Wojciech Polak, Rotterdam, The Netherlands

16:00                      ESOT Education - ESOT Transplant Live & Live Events
                               John Forsythe, Edinburgh, United Kingdom
                               Frank Dor, London, United Kingdom

16:10                      KEYNOTE:  Time is now – modern education
                               William Plant, Cork, Ireland

16:40                      From learners to leaders: introducing the Freudian Walk                          

                               O Captain, My Captain – how the journey continues
                               Luca Toti, Rome, Italy

16:50                      A growing experience – part 1: keeping the balance
                               Maruska Nizzi, Milan, Italy

17:00                      Freudian Walk (3 crews/3 topics about learning/communicating/sharing)

Crew 1 with captain Wojciech Polak, Rotterdam, The Netherlands
Crew 2 with captain Jacopo Romagnoli, Rome, Italy
Crew 3 with captain Luca Toti, Rome, Italy

The Campfire

17:20                      A growing experience - part 2: tips & tricks from senior experts

                               Maruska Nizzi, Milan, Italy

17:30                      Campfire Live (3 crews/3 campfires)

Crew 1 mentored by captain Wojciech Polak, Rotterdam, The Netherlands
Crew 2 mentored by captain Jacopo Romagnoli, Rome, Italy
Crew 3 mentored by captain Luca Toti, Rome, Italy

17:50                      Sharing is Caring – a “post” to the Leaders
                               Maruska Nizzi, Milan, Italy
                               Luca Toti, Rome, Italy

 

17.00-18.00          THE DEVIL’S ADVOCATE: A MODERATED CONTROVERSY IN BASIC SCIENCE

The format of this session will be the presentation of the article by the author followed by a critical discussion by the “opponent” and a rebuttal and general discussion with the audience. It will be a highly interactive session.

CREATED BY: Olivier Thaunat, Lyon, France
                       Thomas Wekerle, Vienna, Austria

New insights in the priming of recipient's immune system
Donor dendritic cell-derived exosomes promote allograft-targeting immune response.
Liu Q, Rojas-Canales DM, Divito SJ, Shufesky WJ, Stolz DB, Erdos G, Sullivan ML, Gibson GA, Watkins SC, Larregina AT, Morelli AE. J Clin Invest. 2016 Aug 1;126(8):2805-20. doi: 10.1172/JCI84577. Epub 2016 Jun 27

17:00                     Defender: Adrian Morelli, Pittsburgh, United States

17:20                     Opponent:  Gavin Pettigrew, Cambridge, United Kingdom

17:30                     Discussion

Impact of microbiota on transplantation outcomes
The composition of the microbiota modulates allograft rejection
Yuk Man Lei, Luqiu Chen, Ying Wang, Andrew T. Stefka, Luciana L. Molinero, Betty Theriault, Keston Aquino-Michaels, Ayelet S. Sivan, Cathryn R. Nagler, Thomas F. Gajewski, Anita S. Chong, Caroline Bartman and Maria-Luisa Alegre. Journal of Clinical Investigation, June 20, 2016

17:40                     Defender: Maria Luisa Alegre, Chicago, United States

17:50                     Opponent 

18:00                     Discussion

 

17.00-18.00          Brief oral sessions                               

 

18.00-19.30             Corporate Plenary Symposium