Programme at a glance

The latest developments in the field of transplantation

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Sunday 24 September
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MORNING:             SPECIALTY UPDATE SYMPOSIA

                               

11.20-14.30             The coolest clinical trials in transplantation. Sponsored by EUROPE

 

13.00-14.30             Corporate plenary symposia

 

14:45-16:30             OPENING EVENT AND PLENARY SESSION 1 | BIG BANG TRANSPLANTATION

CREATORS: Maarten Naesens, Leuven, Belgium and Gabriel Oniscu, Edinburgh, United Kingdom

Welcome addresses by the Congress chairs, Josep Maria Grinyó, Barcelona, Spain and Stefan Schneeberger, Innsbruck, Austria

The session will take you on a journey from the origins of Transplantation to present day. Recent advances in science open the gate to extending human life, defying nature. However, we are also learning from nature how to extend the life of organs and the entire human body. On the brink of the biggest adventure of the human race, stepping on different planet, we face questions about the very essence of humanity

Lectures:

  • Current patient experience and viewpoint.
  • Hibernation and preservation.
  • Near future: A glimpse into the on-going/near future of transplantation
  • Far future: The human fate from a universal perspective - The race to Mars

Key note presentation: The human fate from a universal perspective - The race to Mars.

 

16.45-18.15             Corporate parallel symposia                             

 

18.30-19.30             Brief oral sessions

                                e-Poster opening

 

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Monday 25 September
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07.30-09.00             EDUCATION TRACK 1: Histocompatibility: your worst nightmare?

CREATOR: Frans Claas, Leiden, The Netherlands

Lectures:

  • Application of Luminex assays before and after transplantation.
  • From actual towards virtual crossmatches.   
  • HLA epitope matching.    
  • Hidden sensitization: the memory B cell repertoire.

 

07.30-09.00             EDUCATION TRACK 2: Live donation

CREATORS: Paolo Muiesan, Birmingham, United Kingdom and Raj Thuraisingham, London, United Kingdom

Lectures:

  • Left lobe replacing right lobe in live liver donation.     
  • Governance and near miss events in live liver donation.
  • Minor clinical abnormalities in kidney donors.
  • Teaching minimally-invasive live donor nephrectomy.

 

08.00-09.00             Full oral sessions

                                Brief oral sessions

 

09:10-10:40             STATE OF THE ART 1 | ORGAN PRESERVATION AND ENHANCEMENTS

CREATORS: Gabriel Oniscu, Edinburgh, United Kingdom and Jacques Pirenne, Leuven, Belgium

2017: A growing need for transplantation and changing demographics that challenge any potential increase in organ transplantation. Clinical efforts and research focus on making more organs function better and creating more organs for the ever-growing demand. The race is on: will it be organ reconditioning or creating more organs off the shelf? This session will discuss some of the recent developments that may make organ shortage a thing of the past

  • Lectures :
  • Organ reconditioning should start in the donor.
  • Ex-situ organ reconditioning: living up to the promise?
  • Origami based tissue engineering
  • Choice cuts: growing organs in alternative environments

 

09:10-10:40             STATE OF THE ART 2 | MIX AND MATCH: THE RIGHT ORGAN FOR THE RIGHT RECIPIENT

CREATORS: Valentin Cuervas-Mons, Madrid, Spain and Eelco de Koning, Leiden, The Netherlands

The right organ for the right patient is a central theme in transplantation. To maintain good clinical transplantation outcome is an increasing challenge in light of both donors and recipients with more unfavourable characteristics that could negatively affect this outcome. In this session we will first focus on global aspects of donation and transplantation and subsequently zoom in on 3 categories of recipients that we commonly encounter in our transplantation clinics. Sergio Leone would name them: The immunized, The old and The diabetic            

  • Lectures :
  • World Overview on Transplantation Activities (A report of the Global Observatory on Donation & Transplantation).
  • The immunized patient.
  • The old patient.
  • The diabetic patient.

 

09:10-10:40             STATE OF THE ART 3 | THE BIOMARKER PERSPECTIVE: PRIME TIME OR PERPETUAL PROMISE?

CREATORS: Oriol Bestard, Barcelona, Spain and Maarten Naesens, Leuven, Belgium

Personalised medicine seems the new Holy Grail in medicine. But is it? And what has been achieved in transplantation?  In this session, we discuss the experiences of large consortia that search for biomarkers in the field of transplantation. Biomarkers for non-invasive diagnosis of rejection, for guidance on immunosuppression and for patient risk stratification. In addition, we learn that the efforts to discover and validate innovative biomarkers are huge and that the pipeline towards clinical implementation is long. Finally, we look into the mirror and the crystal ball,  evaluating the achievements made to date and the promises for the future.

  • Lectures :
  • BIOMARGIN - systems biology for non-invasive diagnosis of rejection.
  • BIO-DRIM - marker-assisted immunosuppression individualisation.
  • CTOT - biomarkers for transplant risk stratification.
  • The biomarker verdict: prime time or perpetual promise?

 

11.10-12.40             BIG BANG 1 | TECHNOLOGY ENHANCED  MEDICINE

CREATORS: Pietro Cippà, Zurich, Switzerland and Olivier Thaunat, Lyon, France

We are living in an fast moving age, where the convergence of rapidly developing technologies are enabling new capabilities with the potential to radically improve and disrupt our day to day life. In this session we invite you to have a glance into the crystal ball to see how the future of transplantation looks like. You will learn a CRISPR way to engineer the human genome and how we will soon operate patients from within thanks to nanorobot surgeons."

  • Lectures :
  • A CRISPR way to engineer the human genome.
  • Operating from within: nanorobotic surgery.
  • How do we exploit best brain in tech, science and med to have a global impact!

 

11.10-12.40             Best abstract challenge

                                Full oral sessions

 

13.00-14.00             Corporate parallel lunch symposia

                                Surrogate Endpoints International Workshop

                                Brief oral sessions

 

14:05-15:35             PLENARY SESSION 2 | TRIALS AND TRIBULATIONS IN TRANSPLANTATION

CREATORS: Marc Dahlke, Regensburg, Germany and Alexandre Loupy, Paris, France

Some of the established frameworks and conventional approaches in transplantation are outdated and hinder further progress in the field: Endpoints such as BPAR may be less relevant in the modern era while surrogate endpoints e.g. for long term Ktx survival are lacking. We herein attempt to shake up your minds a bit and engage in a mind-set that challenges some of the things considered to be "true" or important. Let us rethink the relevance and value of established tools for promotion of progress in clinical science and face the need for change and the challenges that come with it. Welcome to a  session that will be rebellious and provocative but also constructive and productive.

  • Lectures :
  • What to do when randomized controlled trials stop working.
  • I can induce tolerance but nobody wants to believe me.
  • Define Success in the 2017 Transplant World; A Path to happiness.

Key note presentation : Managing Change with Big Data.

 

 

16:00 -17:00            BIG BANG 2 | VALUE AND COSTS OF SCIENCE AND PATIENT CARE IN TRANSPLANTATION: THE UNWANTED TRUTH

CREATORS: Stefan Schneeberger, Innsbruck, Austria and Dorry Segev, Baltimore, United States

Lectures :

  • The price for progress.
  • The changing circumstances in health care and their consequences.
  • The price for patients satisfaction.

 

16.00-17.00             Modern education

                                Brief oral sessions

 

16.00-18.00             Full oral sessions

                                               

17.00-18.00             Transplant campfire

                                The Devil's Advocate - Contradictory discussion of Basic Science

                                Brief oral sessions

 

18.00-19.30             Corporate Plenary Symposium

 

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Tuesday 26 September
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07.30-09.00             EDUCATION TRACK 3 : Above and below the diaphragm

CREATORS: Arne Neyrinck, Leuven, Belgium and Annemarie Weissenbacher, Oxford, United Kingdom

Lectures :

  • Old and new listing criteria for  lung and heart transplantation.
  • Old and new listing criteria for liver, pancreas and intestinal transplantation.
  • How do factors from above the diaphragm impact on the outcome of organ Tx below the diaphragm?
  • Combined transplanted patients - Which organ drives the immunosuppressive regimen?

 

07.30-09.00             EDUCATION TRACK 4 : Pathophysiology and endpoints on tolerance

CREATORS: Mark Dahlke, Regensburg, Germany and Henri Leuvenink, Groningen, The Netherlands

Lectures :

  • Necroinflammation in the amplification of organ damage.

 

08.00-09.00             Full oral sessions

                                Brief oral sessions

 

09:10 - 10:40           STATE OF THE ART 4 | NEW CONCEPTS IN TRANSPLANT INFECTIOUS DISEASES: MICROBIOTA, AND BEYOND

CREATORS: Marina Berenguer, Valencia, Spain and Nicolas Mueller, Zurich, Switzerland

Lectures :

  • Transkingdom interplay - the complex interactive world of the microbiome.
  • Knowledge and clinical applications of microbiota in transplantation.
  • Viruses and recipient immune response: relevant crosstalk in transplantation.
  • The impact of HCV treatment on liver transplantation.

 

09:10 - 10:40           STATE OF THE ART 5 | CELL THERAPY IN CLINICAL TRIALS

CREATORS: Marc Dahlke, Regensburg, Germany and Pietro Cippà, Zurich, Switzerland

Cell therapy offers great hope for being a suitable adjunct to conventional immunosuppression with all its downsights, however major issues emerged in the long translation process towards the clinic. How can technical and regulatory hurdles be overcome within a realistic time frame? Will cell therapy be commercially interesting and will its implementation relaunch solid organ transplantation? Experts share their experience and explain what we might expect from cell therapy for tomorrow and in 10 years.

Lectures :

  • Technical and regulatory issues. From the idea to the clinical application.
  • Sharing clinical experience. What can we learn from hematologists?
  • Translational studies. Why do we need cell therapy if we cannot avoid severe immunosuppression?
  • The future: Clinical applications of stem cells, transplantation vs. regeneration? Clinical applications of stem cells, transplantation vs. regeneration?

 

09:10 - 10:40           STATE OF THE ART 6 | ONE FOR ALL OR ALL FOR ONE; GETTING AWAY FROM PROTOCOLIZED MEDICINE

CREATORS: Georg Boehmig, Vienna, Austria and Nicolas Mueller, Zurich, Switzerland

The ultimate goal of transplantation is long-term survival with a well-functioning graft. Operationalization of post-transplant care with protocols based on evidence from clinical trials has had an important impact on the overall quality after transplantation. It is increasingly recognized though that the ‘one size fits all’ approach does not always optimally reflect the patient’s individual need. Hence, the concept of personalized medicine is on everyone's lips. This session aims to confront the reality by asking the following questions, focusing on four important topics in the field.

Lectures :

  • Personalized medicine now and in 10 years.
  • Individualized antimicrobial  prophylaxis.
  • Phenotypic diversity of rejection and allograft dyfunction.
  • Tailored immunosuppression.

 

11.10-12.40             BIG BANG 3 | INNOVATION IN IMMUNOMEDICATION: THE MODERN PROMETHEUS

CREATORS: Josep Maria Grinyó, Barcelona, Spain and Olivier Thaunat, Lyon, France

Putting their steps in those of Dr Frankenstein, scientists have started stitching disparate biological pieces to create new therapeutic opportunities. Far from Sci-Fi fantasies, these therapeutic innovations have already shown promising results in the field of cancer therapy. Their potential to revolutionize solid organ transplantation will be scrutinized during this Big Bang session.

 

11.10-12.40             Asia leading the way

                                Full oral sessions

 

13.00-14.00             Corporate Parallel lunch Symposia

                                Rising the stars on Stage

                                Brief oral sessions

 

14:05-15:35             PLENARY SESSION  3 | INNOVATION UNDER PRESSURE: TRANSPLANT PATIENT CARE IN 2020

CREATORS: Marina Berenguer, Valencia, Spain and Antonio Roman, Barcelona, Spain

Health care is undergoing a fundamental change. While new fields in medicine are emerging and short-term results are satisfactory, long-term care of patients after transplantation is more complex and challanging then ever. While novel technologies may help to effectiverly monitor patients after transplantation, novel structures and business models are warranted to ensure optimal patient care and advancement of the field.

Lectures :

  • Prospects and pushbacks in hand face uterus abdominal wall penile transplant and others.
  • Beyond Survival: Quality of life after transplantation.
  • New tech for new patients: digital communication and self-monitoring.

Key note presentation : New models for patient care: wish for what you care for

 

16.00-17.00             BIG BANG 4 | AGEING AND IMMORTALITY

CREATORS: Maarten Naesens, Leuven, Belgium and Olivier Thaunat, Lyon, France

In this session, we discuss the changing demographics of donors and recipients, and the impact on transplantation (organ quality, ischemia-reperfusion injury and immunosenescence). Transplant allocation organisations are implementing age-matching in their allocation procedures. The benefits and the potential drawbacks of these important changes are discussed. In addition, the biology of ageing, and the concept of accelerated ageing after transplantation is covered in BB4, with illustrations of the great relevance of ageing for the future of patients and grafts. Finally, we evaluate innovative ways to halt or slow down these ageing processes, and discover the clues to immortality.

Lectures :

  • Older graft, older recipients, young ideas.
  • Accelerated ageing after transplantation.
  • Halting aging: the science of rejuvenation.

 

16.00-17.00             The Devil's Advocate ( Clinical )

                                Brief oral sessions

 

17.00-18.30             Corporate Plenary/Parallel Symposium

                                Full oral sessions

 

18.30-19.30             ESOT General Assembly

                                Elevator pitch

                                Brief oral sessions

 

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Wednesday 27 September
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07.30-09.00             EDUCATION TRACK 5 : Infection diseases

CREATORS: Frederike Bemelman, Amsterdam, The Netherlands and Marina Berenguer, Valencia, Spain

Lectures :

  • Prophylaxis of infections in solid organ transplantation (including donor derived infections).
  • Infectious diseases in the central nervous system of Solid Organ Transplant patients            .
  • Fungal and Yeast Infections in SOT patients.
  • Impact of Infection on Chronic Allograft Dysfunction and Allograft Survival After Solid Organ Transplantation.

 

07.30-09.00             EDUCATION TRACK 6 : Allograft phenotype and clinical implications

CREATORS: Maarten Naesens, Leuven, Belgium and Marlies Reinders, Leiden, The Netherlands

Lectures :

  • Allo-immune responses: what a clinician should know.
  • Rejection phenotypes across organs: revisiting the basics.
  • How to integrate complex histological phenotypes in routine clinical decision making?     
  • Time to make computer-assisted instead of eminence-based decisions?

 

08.00-09.00             Full oral sessions

                                Brief oral sessions

 

09:10 - 10:40           STATE OF THE ART 7 | DONOR MANAGEMENT 

CREATORS: Arne Neyrinck, Leuven, Belgium and Jacques Pirenne, Leuven, Belgium

The pre-requisite for successful transplantation is the recruitment of organs of acceptable quality in order to limit the mortality on the waiting list and to guarantee optimal short- and long-term outcome. During the last years, we have experienced a renewed interest in strategies to optimize donor management, especially since liberalization of donor criteria has been introduced within the field.  In this session, we want to address the question if we can still extend the potential donor pool. Therefore the focus will be directed towards recent innovative approaches and towards potential risk factors that might limit further expansion.  The session wants to involve all professionals involved, including anaesthesiologists, intensivists, nurses, coordinators and transplant physicians.

Lectures :

  • How controlled is my DCD?
  • Should I perfuse my donor?
  • Tribulation in designing donor  intervention studies
  • How clean is my donor?

 

 

09:10 - 10:40           STATE OF THE ART 8 | PUSHING THE BOUNDARIES IN LIVING DONATION

CREATORS: Frank Dor, London, United Kingdom and Gabriel Oniscu, Edinburgh, United Kingdom

Live donation has become normal practice in many countries. The successful expansion of the acceptance criteria for live kidney donors is now challenged by emerging evidence for an increased relative risk for the development of renal failure on the long run. In this context it is even more important how transplant professionals provide tailor made information and risk assessments. How can we ensure that donors understand the potential risk? Do we have a good screening tool to assess potential psychological risk for live donors? Can we step away from standardized surgical approaches for live donor nephrectomy or is a tailor made approach more desirable? And one of the burning questions in liver transplantation currently is: Should living liver donor transplantation be advocated above deceased donor liver Tx, as is usually the case in kidney Tx ? This session focuses on the balance between Pushing the limits in the context of potential short and long-term complications.

Lectures :

  • To be or not to be a donor?  (How can we make sure potential donors understand the risks?).
  • Psychosocial evaluation of live donors - the need for a tool to determine psychological risk.
  • Tailor Made Live Donor Nephrectomy: a conversation between 2 surgeons.
  • Should live liver donor transplantation be advocated above deceased donor liver Tx?

 

 

09:10 - 10:40           STATE OF THE ART 9 | CELLULAR INTERACTIONS IN REJECTION

CREATORS: Lorna Marson, Edinburgh, United Kingdom and Olivier Thaunat, Lyon, France

Transplant rejection involves a coordinated attack of the graft by the innate and the adaptive immune systems of the recipient. Although direct visualization of this complex cellular interplay, made possible by recent technological progresses, has greatly improved our understanding of rejection pathophysiology, it has also led to unexpected observations. Indeed, like in other chronic inflammatory conditions, organized lymphoid tissue develops within allografts. This session will provide an update on cellular interactions in rejection and will discuss whether intragraft tertiary lymphoid organs contribute to graft rejection and/or tolerance.

Lectures :

  • Visualizing cell traficking underlying allosensitization by two-photon microscopy.
  • T cell migration to vascularized transplants.
  • Lymphoid neogenesis: a tribute to the travellers.
  • Intragraft tertiary lymphoid organs: friends and foes.

 

 

11:00 - 13:00           PLENARY SESSION 4 | LEADERSHIP IN TRANSPLANTATION – Closing Event

CREATORS: Lorna Marson, Edinburgh, United Kingdom and Stefan Schneeberger, Innsbruck, Austria

Leadership is a key element in our professional lives, yet the attention to professionalism in this "sport" has not received much attention. Much of the potential in our professional environment could be mobilized by enhancing the understanding of the principles in modern leadership. In this final plenary session, which will be also a closing event celebration, you will hear from some great leaders from within and outside transplantation. They will discuss leadership styles and give their own stories of leadership. As per the tradition of the ESOT conference, you will also be presented with a summary often most exciting innovations that have been discussed during the Congress in this session.

Lectures :

  • Clinical: What's hot!
  • Basic Science: What's hot!
  • Leadership in Transplantation.

Key note presentation : Leadership.